ABSTRACT
OBJECTIVE:To investigate the effects of zoledronic sodium on fracture healing in patients with thoraco-lumbar spine fracture(TLSF). METHODS:82 patients with TLSF were randomly divided into observation group and control group with 41 cases in each group. All applied pedicle screw fixation. After operation,control group received conventional therapy as calcium supplement,and observation group was additionally given intravenous injection of zoledronic sodium 5 mg on the basis of control group. The change of Imaging parameters 6 months after operation were compared between 2 groups,and the changes of serum PINP,β-CTX and lumbar spine bone mineral density,and fracture healing time were compared 3,6,12 months after operation. RESULTS:The vertebral height,sagittal index,Cobb’s angle of 2 groups were improved 6 months after operation,compared with before operation,with statistical significance (P0.05);the levels of β-CTX and PINP in observation group were lower than that in control group 3,6,12 months after operation, there was statistical significance 3 month after operation(P<0.01);BMD of observation group was higher that of control group 3, 6,12 months after operation,with statistical significance(P<0.05);the fracture healing time of observation group was(13.25± 1.23)weeks,which was shorter than that of control group(14.54±1.49)weeks,with statistical significance(P<0.01). CONCLU-SIONS:For patients with TLSF,postoperative treatment of zoledronic sodium can increase lumbar spine bone mineral density and promote healing.